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KMID : 0043320070300121511
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Archives of Pharmacal Research
2007 Volume.30 No. 12 p.1511 ~ p.1520
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Synthesis of Thiazolo[4,5-d]pyrimidine Derivatives as Potential Antimicrobial Agents
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Habib Nargues S.
Soliman Raafat
El-Tombary Alaa A.
El-Hawash Soad A. M.
Shaaban Omaima G.
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Abstract
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In this study, we report the synthesis and antimicrobial evaluation of several new thiazolo[4,5- d]pyrimidine derivatives, namely 7-substituted amino-5-methyl-3-phenylthiazolo[4,5-d]pyrimidine- 2(3H)-thiones 4a-e, 8, 13, 15, ethyl 2-cyano-2-(7-substituted-5-methyl-3-phenylthiazolo [4,5-d]-pyrimidin-2(3H)-ylidene)acetates 5a-b, 2-(7-substituted-5-methyl-3-phenylthiazolo[4,5- d]pyrimidin-2(3H)-ylidene)malononitriles 6a-b, 5-methyl-7-morpholino-3-phenylthiazolo[4,5-d] pyrimidine-2(3H)-one 7, and 7-[4-(1-substituted-5-phenyl-4,5-dihydro-1H-pyrazolin-3-yl)anilino]-5- methyl-3-phenylthiazolo[4,5-d]pyrimidine-2(3H)-thiones 10-12. Some of the tested compounds were more active against C. albicans than E. coli and P. aeruginosa, and all were inactive against S. aureus
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KEYWORD
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Thiazolo[4, 5-d]pyrimidines, Pyrazolines, Antimicrobial
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